范义辉

发布时间:2023-08-04录入员:

姓名:范义辉

职称:教授

个人简介:江苏海门人,医学博士

专业研究领域:空间基因组学,医学基因组学,表观遗传学,肿瘤学,免疫治疗,自身免疫性疾病,基因功能,蛋白液-液相分离

专著与论集:

1.               Xu YP, Wu YC, Zhang SL, et al. A tumor specific super-enhancer drives immune evasion by guiding synchronous expression of PD-L1 and PD-L2. Cell Reports, 29 (11): 3435-3447 (2019).

2.               Wu YC, Zhao JW, Zhu HL, et al. SPACE: a web server for linking chromatin accessibility with clinical phenotypes and the immune microenvironment in pan-cancer analysis. Cellular & Molecular Immunology, 1712):1294 – 1296. 2020

3.               Wu YC, Yang Y, Gu HY, et al. Multi-omics analysis reveals the functional transcription and potential translation of enhancers.  International Journal of Cancer, 147(8):2210-2224. (2020)

4.               Guo CL, Ni WK, Ma PP, et al. The endoribonuclease N4BP1 prevents psoriasis by controlling both keratinocytes proliferation and neutrophil infiltration.Cell Death and Disease, 12(5):488. (2021).

5.               Fan ZW, Wu CY, Chen MM, et al. The generation of PD-L1 and PD-L2 in cancer cells: From nuclear chromatin reorganization to extracellular presentation.Acta Pharmaceutica Sinica B, 12(3):1041-1053.(2022)

6.               Xiao X #, Fan Yihui #, Li J, et al. Guidance of super-enhancers in regulation of IL-9 induction and airway inflammation. Journal of Experimental Medicine 215(2): 559 – 574 (2018).

7.               Xiao X#, Shi XM #, Fan YH#, et. OX40 inhibits Th17 cells through activation of repressive chromatin remodeling pathways. Immunity 44: 1271-1283 (2016).

8.               Fan YH, Mao RF, Yu Y, et al.USP21 negatively regulates antiviral response by acting as a RIG-I deubiquitinase. Journal of Experimental Medicine211(2):313-328 (2014).

9.               Fan YH #, Ge NL #, Wang XS #, et al. Amplification and over-expression of MAP3K3 gene in human breast cancer promotes formation and survival of breast cancer cells.  Journal of Pathology 232(1):75-86 (2014).

10.            Fan YH, Yu Y, Mao RF. USP4 targets TAK1 to downregulate TNFa-induced NF-kB activation. Cell Death and Differentiation, 18:1547-1560 (2011).

主要科研项目

主持多项省部级以上科研项目,其中包括国家自然科学基金项目4项,江苏省自然科学基金1项,江苏省特聘教授基金。

讲授课程

病原生物学,科研思维案例教学,病原生物学研究进展

指导研究生情况

已毕业博士研究生1名,硕士生7名;在读博士生2名,硕士生5名。

 

 


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