周亚军

姓名：周亚军

职称：教授

个人简介：江苏南通人，医学博士。美高梅MGM33999生物化学与分子生物学教研室工作。硕导及博导。2004年升为美高梅MGM33999生化与分子生物学教研室副教授，2010.8年升为美高梅MGM33999生化与分子生物学教研室教授。曾留学日本德岛大学医学部，美国路易斯安娜州立大学。

专业研究领域：基础医学。研究方向为肝纤维化分子机制。

专著与论集：

发表SCI收录论文30多篇。主要论文如下：

1) Haimeng Tian , Feifan Xu , Feifei Zhao , Nachuan Pan , Sidan Lu , Xin Jia , Yajun Zhou(通讯).  Early-immediate gene Egr1 is associated with TGFβ1 regulation of epigenetic reader Bromodomain-containing protein 4 via the canonical Smad3 signaling in hepatic stellate cells in vitro and in vivo.FASEB Journal. 2022;36:e22605. 

2) Xiaofei Zhu , Xin Jia , Fangyun Cheng , Haimeng Tian , Yajun Zhou(通讯).c-Jun acts downstream of PI3K/AKT signaling to mediate the effect of leptin on methionine adenosyltransferase 2B in hepatic stellate cells in vitro and in vivo. The Journal of Pathology. 2020,252:423-432.

3) Fangyun Cheng , Shengyan Su , Xiaofei Zhu , Xin Jia , Haimeng Tian , Xuguang Zhai , Wei Guan , Yajun Zhou(通讯). Leptin promotes methionine adenosyltransferase 2A expression in hepatic stellate cells by the downregulation of E2F-4 via the β-catenin pathway.FASEB Journal. 2020,34:5578-5589.

4)Haowen Qiao,Qing Cao,Yucheng Fu,Wei Guan,Fangyun Cheng,Juanjuan Wu,Xin Jia,Hongshan Chen,Yajun Zhou (通讯). Sex-determining region Y-box 9 acts downstream of NADPH oxidase to influence the effect of leptin on PPARγ1 expression in hepatic stellate cells.Biochim Biophys Acta-Molecular basis of disease. 2016,1862:2186-2196. (IF=5.089)

5)  Qian Zhou, Wei Guan, Haowen Qiao, Yuanyuan Cheng, Ziqiang Li, Xuguang Zhai, Yajun Zhou (通讯). GATA binding protein 2 mediates leptin inhibition of PPARγ1 expression in hepatic stellate cells and contributes to hepatic stellate cell activation. Biochim Biophys Acta-Molecular basis of disease. 2014,1842(12 Pt A): 2367-2377 (IF=5.089).

6) Zhai Xuguang, Yan Kunfeng, Fan Jiye, Niu Minghui, Zhou Qian. Zhou Yan, Chen Hongshan, Zhou Yajun (通讯). The beta-catenin pathway contributes to the effects of leptin on SREBP-1c expression in rat hepatic stellate cells and liver fibrosis. British Journal of Pharmacology. 2013,169:197-212.

7) Yajun Zhou(通讯), Xin Jia, Jianbing Qin, Cuihua Lu, Huixia Zhu, Xiangyang Li, Xiao Han, Xiaoliang Sun. Leptin inhibits PPARgamma gene expression in hepatic stellate cells in the mouse model of liver damage. Molecular and Cellular Endocrinology. 2010,323:193-200.

8) Jingjing Qian,Xuguang Zhai, Qian Zhou, Yajun Zhou (通讯). β-Catenin pathway is required for TGF-β1 inhibition of PPARγ expression in cultured hepatic stellate cells. Pharmacological Research. 2012, 66:219-225.

9) Qing Cao,Xiaofei Zhu,Xuguang Zhai,Li Ji,Fangyun Cheng,Yiqi Zhu,Pengfei Yu,Yajun Zhou(通讯). Leptin suppresses microRNA-122 promoter activity by phosphorylation of foxO1 in hepatic stellate cell contributing to leptin promotion of mouse liver fibrosis.Toxicology and Applied Pharmacology. 2018,339:143-150.

10) Xuguang Zhai, Fangyun Cheng, Li Ji, Xiaofei Zhu,Qing Cao, Yali Zhang, Xin JIa, Qian Zhou, Wei Guan, Yajun Zhou (通讯). Leptin reduces microRNA-122 level in hepatic stellate cells in vitro and in vivo. Molecular Immunology, 2017, 92:68-75.

主要科研项目

主持国家自然科学基金面上项目4项。

讲授课程

生物化学与分子生物学；临床生化；留学生生物化学与分子生物学。生物化学实验课。

指导研究生情况

已毕业博士生1名，硕士生9名；在读博士生1名，硕士生1名。