姓名：张新化
职称：教授
个人简介：江苏南通人，理学博士，中国解剖学会运动解剖学分会常务委员、江苏省神经科学会理事、江苏省解剖学会理事。入选江苏省“333人才工程”、南通市“226人才工程”培养对象，江苏省优秀青年骨干教师、南通市高校教学名师、文明教工、优秀教育工作者等荣誉称号。2012年至2014年，先后赴澳大利亚LaTrob大学和美国纽约州立基础研究所做访问学者。发表研究性论文50余篇，为多家外文杂志审稿人。主编和参与编写研究性论著4部，教材5部。研究成果获教育部自然科学奖、中华医学科技奖、全国妇幼健康科技奖、江苏省科学技术奖、江苏省医学科技奖、南通市科技进步奖、中国科学十大进展。
主持国家、省部级教改课题5项，国家一流本科课程、省精品课程负责人，国家精品课程、国家级精品资源共享课主讲教师，国家级优秀教学团队核心成员。
专业研究领域：神经再生与神经退行性病
专著与论集：
1) Lei Zhang, Xunrui Zhang, Ruijie Ji, Yaya Ji, Yuhang Wu, Xiuyu Ding, Zhiying Shang, Xueyuan Liu, Wen Li, Jingjing Guo, Jue Wang, Xiang Cheng, Jianbing Qi, Meiling Tian, GuohuaJin, Xinhua Zhang*. Lama2 And Samsn1 Mediate the Effects of Brn4 on Hippocampal Neural Stem Cell Proliferation and Differentiation. Stem Cells Int. 2023 Apr 13; 2023:7284986. doi: 10.1155/2023/7284986.
2) Zhengye Tan, Wen Li, Xiang Cheng, Qing Zhu, Xinhua Zhang*. Non-Coding RNAs in the Regulation of Hippocampal Neurogenesis and Potential Treatment Targets for Related Disorders. Biomolecules. 2022 Dec 22;13(1):18. doi: 10.3390/biom13010018.
3) Li W, Wang SS, Shan BQ, Qin JB, Zhao HY, Tian ML, He H, Cheng X, Zhang XH*, Jin GH*. miR-103-3p targets Ndel1 to regulate neural stem cell proliferation and differentiation.Neural Regen Res. 2022 Feb;17(2):401-408. doi: 10.4103/1673-5374.317987.
4) Chunhua Wan*, Xiaoqin Yan, Baoying Hu, Xinhua Zhang*. Emerging Roles of the Nervous System in Gastrointestinal Cancer Development. Cancers (Basel). 2022 Jul 30;14(15):3722. doi: 10.3390/cancers14153722.
5) Li W, Shan B, Cheng X, He H, Qin J, Zhao H, Tian M, Zhang X*, Jin G*. circRNA Acbd6 promotes neural stem cell differentiation into cholinergic neurons via the miR-320-5p-Osbpl2 axis. J Biol Chem. 2022;298(4):101828; doi: 10.1016/j.jbc.2022.101828.
6) Li W, Wang S, Shan B, Cheng X, He H, Qin J, Tang Y, Zhao H, Tian M, Zhang X*, Jin G*. CircHECTD1 Regulates Cell Proliferation and Migration by the miR-320-5p/SLC2A1 Axis in Glioblastoma Multiform. Front Oncol. 2021 May 17; 11:666391. doi: 10.3389/fonc.2021.666391.
7) Li W, Wang S, He H, Qin J, Cheng X, Zhao H, Tian M, Zhang X*, Jin G*. Expression and function of Ndel1 during the differentiation of neural stem cells induced by hippocampal exosomesticle. Stem Cell Res Ther. 2021 Jan 9;12(1):51. doi: 10.1186/s13287-020-02119-2.
8) Yuying Wu, Xunrui Zhang, Jue Wang, Ruijie Ji, Lei Zhang, Jianbing Qin, Meiling Tian, GuohuaJin, Xinhua Zhang*. P4HA2 promotes cell proliferation and migration in glioblastoma. Oncol Lett. 2021 Aug;22(2):601. doi: 10.3892/ol.2021.12862
9) Wu Y, Zhang X, Wang J, Jin G, Zhang X*. Research progress of the transcription factor Brn4 (Review). Mol Med Rep. 2021 Mar;23(3):1. doi: 10.3892/mmr.2020.11818.
10) Cheng X, Li W, Zhao R, Li H, Qin J, Tian M, Zhang X*, Jin G*. The role of hippocampus niche exosomes in rat hippocampal neurogenesis after fimbria-fornix transection. J Biol Chem. 2020 Dec 17: 296:100188. doi: 10.1074/jbc.RA120.015561.
11) Yong Dai, Feifan Sun, Hui Zhu, Qianqian Liu, Xide Xu, Peipei Gong, Rui Jiang, GuohuaJin, Jianbing Qin, Jian Chen*, Xinghua Zhang*, Wei Shi*. Effects and Mechanism of Action of Neonatal Versus Adult Astrocytes on Neural Stem Cell Proliferation After Traumatic Brain Injury. Stem Cells. 2019 Oct; 37(10):1344-1356.
12) Zhu S, Zhao C, Wu Y, Yang Q, Shao A, Wang T, Wu J, Yin Y, Li Y, Hou J, Zhang X, Zhou G, Gu X, Wang X, Bustelo XR, Zhou J. Identification of a Vav2-dependent mechanism for GDNF/Ret control of mesolimbic DAT trafficking. Nat Neurosci. 2015 Aug; 18(8):1084-93
13) Shao W, Zhang SZ, Tang M, Zhang XH, Zhou Z, Yin YQ, Zhou QB, Huang YY, Liu YJ, Wawrousek E, Chen T, Li SB, Xu M, Zhou JN, Hu G, Zhou JW. Suppression of neuroinflammation by astrocytic dopamine D2 receptors via αB-crystallin.Nature. 2013; 494(7435):90-4.
14) Wei Shi, DekangNie, GuohuaJin, Weiwei Chen, Liang Xia, Xiujie Wu, Xing Su, Xide Xu, Lanchun Ni, Xianan Zhang, Xinhua Zhang*, Jian Chen*. BDNF blended chitosan scaffolds for human umbilical cord MSC transplants in traumatic brain injury therapy. Biomaterials. 2012; 33(11):3119-26.
15) Zhang Xinhua, Jin Guohua, Li Wei, Zou Linqing, Shi Jinhong, Qin Jianbing, Tian Meiling, Li Haoming. Ectopic Neurogenesis in the Forebrain Cholinergic System-Related Areas of a Rat Dementia Model. Stem Cells Dev. 2011; 20(9):1627-38.
16) Xinhua Zhang, Zheng Zhou, Dakui Wang, Aiqun Li, Yanqing Yin, Xiaosong Gu, Fei Ding, Xuechu Zhen, Jiawei Zhou. Activation of phosphatidylinositol-linked D1-like receptor modulates FGF-2 expression in astrocytes via IP3-dependent Ca2+ signaling. J Neurosci 2009; 29(24):7766-7775.
17) Xinhua Zhang, GuohuaJin, Lei Wang, Wenzhong Hu, Meiling Tian, Jianbing Qin, Huiwei Huang. Brn-4 is upregulated in the deafferented hippocampus and promotes neuronal differentiation of neural progenitors in vitro. Hippocampus. 2009; 19(2):176-86.
18) <Hippocampus-Plasticity and Function>. InTech, Croatia, 2018. IBSN: 978-953-51-5739-7
19) <Neural Stem Cell and Therapy>. InTech Press, Croatia, 2012.
20) <Stem Cells Basics and Clinical Translation>. Shanghai Jiao Tong University Press and Springer Press, Shanghai. 2015.
21) <Hippocampus-cytoarchitecture and disease>. InTech Press, Croatia, 2022.
主要科研项目
先后主持完成国家、省部级课题5项，市、厅级课题多项，参与完成多项国家、省部级课题。
讲授课程
系统解剖学、局部解剖学、口腔解剖生理学、断层解剖学
指导研究生情况
已毕业硕士研究生20名；在读硕士生5名。